Avram Holmes is an Assistant Professor of Psychology at Yale. His research program explores the biological pathways that give rise to individual variability in emotional reactivity, with a particular focus on the intersection of emotion and cognition. A core motivation that drives his laboratories’ work is the search for specific neurogenetic signatures associated with individual variations in emotional experience and risk for onset of anxiety and affective illnesses such as major depressive disorder. With the expanding array of brain imaging and genetic methods and analysis procedures, there is an increasing need for robust computational platforms where researchers can process the large-scale datasets necessary to link neurogenetic data with clinical, behavioral, and healthy outcomes. The Yale University high performance computing (HPC) facilities are an essential part of the Holmes lab’s research program. Lab members utilize the HPC facilities to integrate and mine neuroimaging, genetic, and associated behavioral data.